Elucidation of the mechanisms by which paired immune receptors regulate hepatic ischemia reperfusion injury

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17000
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Juntendo University
• Principal Investigator: Yin Enzhi 順天堂大学, 大学院医学研究科, 非常勤助教 (70844786)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 虚血再灌流障害 / 肝臓 / ペア型免疫受容体

Outline of Final Research Achievements

We used murine models of hepatic ischemia reperfusion injury in wild-type, an inhibitory receptor-deficient, and an activating receptor-deficient mice. Loss of an inhibitory receptor tested did not significantly influence hepatic ischemia reperfusion injury. In contrast, loss of an activating receptor tested reduced the numbers of neutrophils recruited to and the levels of inflammatory cytokines in the liver following ischemia-reperfusion, thereby alleviating the hepatic damage. Thus, the deficiency of an activating receptor tested, specifically expressed in neutrophils, exacerbated hepatic ischemia reperfusion injury.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究により、ペア型免疫受容体ファミリーに属する特定の活性化型受容体が肝臓虚血再灌流障害を悪化させる働きをもつことが明らかになった。好中球に特異的に発現する活性化型受容体が虚血再灌流した肝臓への好中球集積を促進し、炎症を誘導し、肝障害を悪化させると考えられた。これらの研究成果は、肝臓虚血再灌流障害の病態機序の解明と予防・治療法の開発につながり、学術的意義と社会的意義を有すると考えられる。