The impact of selecting activation timing based on peak-frequency calculated by omnipolar technology on 3D-mapping

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17074
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takigawa Masateru 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 (40760062)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 局所電位 / 周波数 / 電位高 / オムニポーラー / 双極電位 / 局所興奮

Outline of Final Research Achievements

Usually, local activation timing is demonstrated by the dv/dt of bipolar voltages, so that it is frequently affected by the bipolar amplitudes. In such case, large far-field effect may mask the activation of the small musculature close to the large volume of healthy muscle. The novel algorithm, using omnipolar technology calculate the peak-frequency of the local electrogram, and define the local activation timing as the sharpest segment in the electrogram. This may enable to detect the gap more accurately, and show the activation more precisely. However, the results showed that not a remarkable difference was observed between the dv/dt-based map and peak-frequency based map.

Free Research Field

臨床電気生理学、不整脈学

Academic Significance and Societal Importance of the Research Achievements

電位高は、本領域において長く使用されてきたパラメータである。例えば、双極電位で心房電位＜0.5mV、心室電位＜1.5mVは異常低電位領域とされてきたが、これはかなり経験的に決めれられたにもかかわらず、長く臨床においても使用されている。しかしながら、peak-frequencyは電位高とは、正常値における分布も異なっており、同様の情報を表しているものではない。この新たな指標を相補的に使用することにより、複雑な不整脈の機序の解明に役立つ可能性がある。