2022 Fiscal Year Final Research Report
Human induced pluripotent stem cell derived cardiomyocyte maturation by DNA integrative free-delivery of key regulators
| Project/Area Number |
20K17078
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 53020:Cardiology-related
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | Cardiac maturation / TNNI3 / hiPSC-CM / Stem Cell Research / Cell Cycle |
|---|
| Outline of Final Research Achievements |
We extensively worked in developing safe methods to increase the maturation of hiPSC-derived cardiomyocytes to improve clinical applications in regenerative medicine.
Eventually, we developed methods to increase the adult-like properties of hiPSC-CM that can be transferred to clinical applications.
|
| Free Research Field |
Stem Cell Research in Cardiovascular Biology
|
| Academic Significance and Societal Importance of the Research Achievements |
We developed methods with clinical applications to increase the maturation of cardiac tissues derived from human iPS exploiting the control of the cardiac cell cycle.
|
