2023 Fiscal Year Final Research Report
The role of reparative monocytes in tissue repair during left ventricular remodeling after myocardial infarction
| Project/Area Number |
20K17086
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 心筋梗塞 / 心筋組織修復 / 炎症 / 単球 / ワクチン |
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| Outline of Final Research Achievements |
The increasing incidence of heart failure in patients following acute myocardial infarction remains an unresolved medical challenge. We aimed to elucidate the mechanisms of cardiac tissue repair by reparative monocytes in left ventricular remodeling through the depletion of inflammatory monocytes using Ly-6C vaccination. Following myocardial infarction in Red-green mice, we confirmed the accumulation of RFP-positive CCR2-positive monocytes on day 3 and GFP-positive CX3CR1-positive monocytes on day 7 in the ischemic myocardium. To deplete inflammatory monocytes, we developed a Ly-6C vaccination to induce Ly-6C antibody production in the blood, which resulted in a decrease in Ly-6C monocytes in peripheral blood upon vaccination. Building upon this research, we will elucidate the mechanisms underlying the accumulation of reparative monocytes in the post-infarction myocardium in the future.
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| Free Research Field |
血管生物学
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| Academic Significance and Societal Importance of the Research Achievements |
心筋梗塞後の急性炎症に反応して修復性単球による炎症の収束と心臓組織修復（心筋細胞の脱落にともなう線維化）が進行するが、その過程の詳細は明らかではない。不十分な心臓組織修復は、心破裂や左室リモデリングによる心不全を誘導し、生命予後及び生活の質を著しく損なう。現状はアンギオテンシン系阻害薬やβ遮断薬などの対症的治療しかなく、心臓組織修復の新規治療法の開発にはその分子細胞機序の解明が急務である。これまで有効な薬剤や低侵襲医療のなかった領域に対する革新的治療戦略の創出へとつながれば、科学研究上のインパクトや社会への貢献度は極めて高い。
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