2022 Fiscal Year Final Research Report
Pathological analysis of the arteries after endovascular treatment for lower extremity artery disease
| Project/Area Number |
20K17097
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 53020:Cardiology-related
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
TORII Sho 東海大学, 医学部, 講師 (80816570)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | Medial calcification / Monckeberg calcification / Peripheral artery / LEAD / Hemodialysis / CLTI / Endovascular therapy |
|---|
| Outline of Final Research Achievements |
In this study, specimens that were amputated or pathologically dissected in the lower extremity despite endovascular treatment were collected and the post-treatment vessels were examined pathologically. Seventy-seven arteries were collected, resulting in a total of 2,319 pathological sections.
About half of the specimens collected were from dialysis patients, and the evaluation focused on the differences in the progression of atherosclerosis between dialysis and non-dialysis patients.
Results showed that dialysis patients differed more markedly from non-dialysis patients in terms of medial calcification than did non-dialysis patients. The differences were particularly pronounced in the below-knee lesions of non-dialysis patients, suggesting that hemodialysis play an important role in the mechanism of calcification.
|
| Free Research Field |
心血管病理
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究において透析患者と非透析患者の下肢動脈の動脈硬化、および石灰化の進行過程の違いが病理学的に明らかになった事により、
１、透析患者に対する血管内治療の際にしばしば見受けられる高度石灰化病変に対する治療方針が変わる可能性がある
２、透析そのものが中膜の石灰化のリスクである事を示した事により今後の石灰化に関わる基礎研究において有益な情報になりうる
|
