Development of bone marrow targeting therapy against atheresclerosis

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17152
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kobe University
• Principal Investigator: Emoto Takuo 神戸大学, 医学研究科, 医学研究員 (80855023)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 骨髄 / 単球 / 動脈硬化

Outline of Final Research Achievements

We tried to clarify atherosclerosis specific monocyte population in blood and bone marrow by single cell RNA sequencing. Although we fined an increase of monocyte population in bone marrow, we could not find atherosclerosis specific cell populations in bone marrow or bone marrow niche.
Single-cell RNA sequencing revealed more monocytes, mast cells and inflammatory macrophages accumulated in coronary plaques involved in acute coronary syndrome in comparison to culprit plaques for chronic coronary syndrome.

Free Research Field

動脈硬化

Academic Significance and Societal Importance of the Research Achievements

動脈硬化における骨髄での単球増加を示すことができた。特異的な細胞集団の発見にまではいたらなかったが、骨髄の単球造血が動脈硬化に与える影響の一端を示すことができたと考える。