2023 Fiscal Year Final Research Report
Association between non-alcoholic fatty liver diseases related genetic polymorphism, lipid metabolism, and atherosclerosis
| Project/Area Number |
20K17155
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | NAFLD / MASLD / 動脈硬化症 / リポ蛋白 / SNP |
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| Outline of Final Research Achievements |
In this study, we investigated the impact of non-alcoholic fatty liver disease (NAFLD) related SNPs on atherosclerosis and lipid metabolism, using data from a 5-year prospective observational study. Analysis targeting approximately 1000 individuals without hypertension, diabetes, or dyslipidemia revealed that the minor allele of NCAN carriers had a significant lower risk of developing new atherosclerosis five years later. Another analysis involving approximately 1500 individuals with either hypertension, diabetes, or dyslipidemia showed that minor allele of TM6SF2 and GCKR carriers had significant lower levels of atherogenic lipoproteins such as LDL cholesterol.
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| Free Research Field |
脂質代謝・動脈硬化症・糖尿病
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| Academic Significance and Societal Importance of the Research Achievements |
日本人の死因やADL低下の原因として重要な心筋梗塞や脳梗塞などの動脈硬化性疾患の予防として、高血圧や糖尿病、脂質代謝異常の治療・予防が挙げられる。近年、非アルコール性脂肪肝/脂肪肝炎（NAFLD）が動脈硬化症のリスクとなることが注目されている。本研究ではNAFLD関連遺伝子と動脈硬化および脂質代謝異常との相関について、日本人の前向き観察研究のデータを用いて解析を行った。NAFLD関連遺伝子の中で、NCANの変異は動脈硬化に保護的、TM6SF2とGCKRの変異は脂質代謝異常に対して保護的であることが示された。今後はNAFLD関連遺伝子変異が動脈硬化性疾患に対して与える影響の検討が必要である。
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