Effect of Bone Cytokines on Cardiac Prognosis of Heart Failure patients

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17157
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: ABE SATOSHI 福島県立医科大学, 医学部, 助教 (30722508)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 心不全 / 骨代謝

Outline of Final Research Achievements

The relationship between Osteoprotegerin(OPG), a hormone related to bone metabolism, and prognosis of heart failure has already been reported. In this study, TRACP-5b, a bone metabolism marker, was positively correlated with OPG, and was associated with prognosis in　heart failure patients. I presented the result of our study at the American Heart Association (AHA) and the Japanese Society of Cardiology scientific sessions, and a paper was submitted to CJC Open and accepted.

Free Research Field

循環器内科　心不全

Academic Significance and Societal Importance of the Research Achievements

日常診療で骨代謝ホルモンであるOPGを測定することは現実的に困難である。OPGと心不全の予後ならびにTRACP-5bとの関連が明らかになったことで、日常診療で測定できるTRACP-5bが心不全の予後を規定する因子になりうる。また、心不全リスク層別化および管理の指標のひとつとして活用することができ、心不全診療の改善に寄与するものと考える。