2023 Fiscal Year Final Research Report
Regulation of obesity related severe asthma, role of glucagon-like peptide-1
| Project/Area Number |
20K17184
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 53030:Respiratory medicine-related
|
|---|
| Research Institution | Saga University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | 気管支喘息 / 増悪 |
|---|
| Outline of Final Research Achievements |
TSLP contributes to ozone-induced exacerbations of eosinophilic airway inflammation and provide greater understanding of ozone-induced severity mechanisms in the pathophysiology of asthma related to TSLP and G-CSF.
|
| Free Research Field |
気管支喘息
|
| Academic Significance and Societal Importance of the Research Achievements |
今回TSLPが喘息増悪に関与していたことを発見したこととから、腸内細菌叢の変化がTSLPの動態に関与している可能性や、GLP-1の分子自体が関与している可能性が考えられ、今後研究を継続していく予定にしている。
|
