New therapeutic strategies for insulin resistance through bone and mineral metabolism

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17259
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Nakashima Akio 東京慈恵会医科大学, 医学部, 助教 (20624688)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: インスリン抵抗性 / 骨・ミネラル代謝 / 血液透析

Outline of Final Research Achievements

The number of diabetic patients is increasing all over the world, and therapeutic strategy are urgently needed for medical staffs. Insulin resistance is a major factor in the pathogenesis of diabetes mellitus and has been reassessed in recent years. However, there are few interventions for insulin resistance, and the treatments are limited. We have clarified that phosphorus and phosphorus excretion hormone FGF23 are involved in insulin resistance in diabetic patients, and also analyzed the prognosis of life. As a result, a significant correlation was found between insulin resistance and mineral-bone metabolism, demonstrating that both affect prognosis.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

本研究課題ではリン代謝に関与するFGF23とインスリン抵抗性との関係性を明らかにし、骨・ミネラル代謝とインスリン抵抗性の両者が相まって腎不全患者/血液透析患者の生命予後や心血管疾患に関与することを示した。その機序として骨・ミネラル代謝による血管石灰化の進展が考えられた。今後、骨・ミネラル代謝を通じた新たなインスリン抵抗性や糖尿病への治療に結びつく可能性を秘めており、腎不全患者に与える影響は大きいと考えられる。