Basic research to elucidate strategies for prevention and treatment against acute kidney injury through regulating apoptosis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17288
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Kumamoto University
• Principal Investigator: Morinaga Jun 熊本大学, 病院, 病院教員 (50459210)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 急性腎障害

Outline of Final Research Achievements

Acute kidney injury is a risk for developing chronic kidney disease and shortening the life span of people. Thus, finding strategies for prevention and treatment of the acute kidney injury is desired. Currently, the applicant of this grant found that a family member of angiopoietin-like protein (ANGPTL) have a favorable effect on the progression of acute kidney injury. In this project, the applicant will explore the molecular mechanism of acute kidney injury through the ANGPTL mediated mechanisms.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

急性腎障害は世界的な健康問題であり、人口 10万人当りのAKIの発症頻度は、透析が必要ない症例と透析が必要な症例でそれぞれ約 200～500 件年，約 20～30 件年と高い。本研究において申請者は、アンジオポエチン様因子を介した急性腎障害進展のメカニズムを一部明らかにすることで、当該疾患に対する予防法および治療法のための分子基盤構築に寄与し、医学へ貢献することが可能である。