2022 Fiscal Year Final Research Report
Establishment of predictive factors for the development of nephritis in IgA vasculitis
Project/Area Number |
20K17294
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | IgA血管炎 / IgA腎症 / 腎炎 / 糖鎖異常IgA1 / KM55染色 |
Outline of Final Research Achievements |
The renal prognosis in adult-onset cases of IgA vasculitis(IgAV) is poor, but the pathogenesis of the disease is unclear; since the glycosylation abnormality IgA1 has been implicated in the pathogenesis of IgA nephropathy, we decided to establish predictive factors for the development of nephritis in IgA vasculitis in the present study. A total of 13 patients with IgAV with purpura as the initial symptom were recruited, and serum biomarkers (IgA, IgA-IgG immune complex, and glycosylated abnormal IgA1) and urinary glycosylated abnormal-IgA1, which have been implicated in the pathogenesis of IgA nephropathy, were measured. There was no predominant difference in these biomarkers between nephritis-associated and nephritis-unassociated cases, and the results of the present study do not indicate that IgAV is a valid biomarker that can predict the development of nephritis.
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Free Research Field |
腎炎
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Academic Significance and Societal Importance of the Research Achievements |
IgA血管炎の成人発症例における腎予後は悪く、早期診断・早期治療介入が必須であるが、その病態は明らかではない。IgA腎症とIgA血管炎の腎炎合併例は類似性があることがわかっており、またその病態には糖鎖異常IgA1が関与していることがわかっている。今回はIgA血管炎における腎炎発症の予測因子の確立を目的とした。紫斑を初発症状とするIgA血管炎患者を対象に、糖鎖異常IgA1等のバイオマーカーの測定を行った。腎炎合併例と腎炎非合併例でこれらのバイオマーカーに優位差はなく、今回の研究ではIgA血管炎の腎炎発症を予測しうる有効なバイオマーカーとはいえない結果であった。
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