Chontrol of inflammatory skin diseases by selective Wnt/beta-catenin/CBP signal inhibition

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17321
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Oita University
• Principal Investigator: Hirose Haruna 大分大学, 医学部, 助教 (50750915)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: アトピー性皮膚炎 / 乾癬 / Wnt/β-catenin/CBP

Outline of Final Research Achievements

We analyzed the effect of selective Wnt/β-catenin/CBP signaling inhibition (ICG-001) in a mouse model of imiquimod-induced psoriasis. No significant effects were found on dermatitis score, pathological findings, or inflammatory cytokines expression. Using RNA sequencing analysis, gene expression comparison, clustering, and upstream analysis were performed. As a result, up-regulated genes and down-regulated ones were identified. These results indicate that ICG-001 has no inhibitory effect on psoriasis-like dermatitis. On the other hand, ICG-001 treatment was found to alter a number of genes.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

アトピー性皮膚炎モデルでは炎症抑制効果を認めた選択的Wnt/β-catenin/CBPシグナル阻害（ICG-001）が乾癬モデルで効果を認めなかったことから、Wnt/β-catenin/CBPシグナルの観点で、アトピー性皮膚炎と乾癬の病態に違いがあることが示唆された。この結果は、炎症性皮膚疾患の病態研究においてWnt/β-catenin/CBPシグナルが研究標的となり得ることを示唆している。特に、真皮のリモデリングが病態形成において重要か否かの違いを反映していることが推察される。