2021 Fiscal Year Final Research Report
Mechanistic understanding of differentiation between epidermis and follicular epithelium, by using two types of atheroma.
| Project/Area Number |
20K17322
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | アテローム / 表皮嚢腫 / 粉瘤 / 外毛根鞘嚢腫 / 毛包性角化 / 表皮角化 / トランスクリプトーム解析 / 毛包分化 |
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| Outline of Final Research Achievements |
Based on the histopathological characteristics of epidermal cysts and external hair follicle sheath cysts, we reviewed the diagnosis and picked up 9 cases of epidermal cysts and 7 cases of external hair follicle sheath cysts. principal component analysis between the 2 groups showed that the gene expression patterns were very similar. The analysis between the two groups of 9 epidermal cysts and 6 external hair follicle sheath cysts was able to pick up several candidate genes with statistically significant differences. Enrichment analysis in the epidermal cyst group showed high expression of genes related to keratinazation and epidermis development. In the external hair follicle sheath cyst group, genes related to central nerves system development were highly expressed.
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| Free Research Field |
皮膚科
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| Academic Significance and Societal Importance of the Research Achievements |
現在のところ、皮膚疾患における次世代シークエンスによるトランスクリプトーム解析は、乾癬やアトピーなどの大規模な疾患での商業的解析や、皮膚癌のドライバー遺伝子のスクリーニング、治療関連遺伝子の探索に限られている。本研究では、表皮嚢腫と外毛根鞘嚢腫の２型のアテローマを検体とすることで、それぞれの発生母地である毛包間表皮と毛包上皮の分化形態の表現型や誘導因子を探索する。毛包組織は複雑な組織内組織であり、一つの幹細胞から誘導する因子が何であるか、表現型の違いには何があるのかを明らかにできれば、皮膚の生理学的発生の解明の一助となる。
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