Search for disease susceptibility genes for omega-5 gliadin sensitized wheat allergy

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17350
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Shimane University
• Principal Investigator: OTA MASATAKA 島根大学, 学術研究院医学・看護学系, 講師 (90710111)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 疾患感受性遺伝子 / ω-5グリアジン / WDEIA

Outline of Final Research Achievements

Whole-genome analysis was performed on 77 WDEIA patients and 924 healthy controls with ω-5 gliadin-specific IgE levels of 0.70 kUa/L or higher to identify disease-sensitive genes by GWAS study and HLA gene analysis of ω-5 gliadin-sensitized wheat allergy patients who visited Shimane University Hospital.
The development of a simple detection method for genes that was planned this time has not yet been developed, and it is a future research topic.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

これまでアレルギー性疾患の疾患感受性遺伝子を利用した発症予防の取り組みはあまり前例がなく、本研究は独自性の高い研究と考えている。本研究が成功すれば、小麦アレルギーの発症を抑制することに繋がり、国民のQOLの向上に繋がるのみならず、医療費の削減にも貢献できると考
えている。