Physiological function of phosphatidylinositol phosphate in human erythropoiesis.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17367
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Akita University
• Principal Investigator: Asanuma Ken 秋田大学, 医学系研究科, 総括技術長 (50710125)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: ヒト赤芽球 / ホスファチジルイノシトール / ホスファチジルイノシトール3キナーゼ

Outline of Final Research Achievements

The Class Ⅲ phosphoinositide 3-kinase, PIK3C3 is known to contribute to autophagy and regulate intracellular membrane trafficking. However, the role of PIK3C3 in human erythropoiesis is little known. In this study, we elucidate that the amount of intracellular phosphatidylinositol 3-phosphate (PI(3)P) increased relative to its precursor phosphatidylinositol (PI) as human erythroblasts mature, and the PIK3C3 protein expression level is highly maintained until enucleation. These findings suggest that PIK3C3 and its product, PI(3)P, might be positive regulators for human erythropoiesis.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

ヒト赤芽球の分化過程にPIK3C3並びにPI3Pが関与する可能性を初めて示した事に学術的意義がある。
分化した赤血球は脱核しているが故に自己増殖能がなく、深刻な貧血をもたらす血液疾患罹患者は献血による血液製剤を用いた輸血に頼らざるを得ない。赤血球の分化をPIK3C3並びにPI3Pが正に制御する可能性を見出した事は、赤血球の工業生産への応用へとつながる可能性があり社会的意義がある。