Elucidation of the regulatory mechanism of activated regulatory T cells in hematopoietic malignancies

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17391
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: National Cancer Center Japan
• Principal Investigator: Yuda Junichiro 国立研究開発法人国立がん研究センター, 東病院, 医長 (20813934)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 造血器悪性腫瘍 / 制御性T細胞 / 白血病 / リンパ腫 / トランスクリプトーム解析 / オープンクロマチン解析

Outline of Final Research Achievements

In order to clarify the importance of activated regulatory T cells in the tumor environment and their activation regulation mechanism, we started a study to characterize regulatory T cells in the tumor environment using cross-organ samples of solid tumors and hematopoietic malignancies. First of all, regulatory T cells are a very small population, and only a small number of regulatory T cells infiltrate the tumor local area. Therefore, we established an experimental system that enables transcriptome analysis and open chromatin analysis by collecting activated regulatory T cells infiltrating the tumor local area using a cell sorter. Using this experimental system, we analyzed regulatory T cells infiltrating the tumor local area using samples of lung cancer and hematopoietic malignancies.

Free Research Field

造血器悪性腫瘍

Academic Significance and Societal Importance of the Research Achievements

造血器悪性腫瘍の病勢進展における制御性T細胞の役割、その活性化機序を示した研究成果が少ない。固形がんとの共通する役割や活性化機序、造血器悪性腫瘍に特徴的な活性化機序を明らかにする研究意義は大きい。