2022 Fiscal Year Final Research Report
Elucidation of the pathogenesis of RA focusing on oral microme and ACPA maturation
| Project/Area Number |
20K17427
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
Tsuji Yoshika 長崎大学, 病院(医学系), 助教 (10866297)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 口腔内細菌叢 / 抗CCP抗体 / 関節リウマチ |
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| Outline of Final Research Achievements |
A total of 1284 healthy subjects were analyzed. Median age was 69.0 (Interquartile range 62.0-76.0), and 20 samples were ACPA-positive. Comparison of alpha diversity based on the Shannon index showed no significant difference between ACPA-positive and ACPA-negative subjects, while beta diversity showed a predominance of Pasteurellaceae among ACPA-positive healthy subjects, and a decrease in Neisseriaceae and Pasteurellaceae may contribute to the production of APCA.
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| Free Research Field |
膠原病およびアレルギー内科学関連
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| Academic Significance and Societal Importance of the Research Achievements |
関節リウマチ（RA）の有病率１％と比較的高く，生物学的製剤やJAK阻害薬など治療法の選択肢の増加に伴い，関節機能の温存や生命予後の改善など健常者と相違ない生活を手に入れることも期待できる時代となった．しかし一方で、これらの薬剤は医療費を押し上げた一因となったことは否めない．関節リウマチの発症リスクは遺伝的要因よりも環境要因の割合が高いことが知られており，今後は早期発見，ひいては予防の観点から本疾患を見つめ直すことが重要である．本研究は比較的検体採取の容易な唾液検体を用いてACPAの産生に寄与する口腔内細菌叢を解析しRAハイリスク者の特定の一助となり社会的意義が大きいと考えられる．
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