Exploratory research on novel treatment for short stature by elucidating the regulatory mechanism of CNP expression

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17490
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Kyoto University
• Principal Investigator: Ueda Yohei 京都大学, 医学研究科, 特定助教 (30848213)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: CNP / 低身長症 / 成長因子

Outline of Final Research Achievements

Recently, C-type natriuretic peptide (CNP) has been reported to promote bone elongation and is now in clinical use as a novel therapeutic agent for short stature. However, there are still some points that need to be improved, such as the need for daily injections, which is burdensome for children.
The purpose of this study is to elucidate the regulatory mechanism of CNP production and to establish a safer and simpler treatment method for short stature by expanding the treatment options for short stature by the bone elongation effect of CNP. In this study, we found that CNP production is regulated by different mechanisms in the growth plate cartilage, the center of growth, and in other tissues.

Free Research Field

内分泌学

Academic Significance and Societal Importance of the Research Achievements

C型ナトリウム利尿ペプチド(CNP)は低身長症に応用されるようになってきているが、一方で生体内でのCNP発現調節機構は不明であり、これを解明することはCNP発現調節を利用した低身長症の新規治療法開発につながるため、社会的意義のあるものである。今回の研究では、成長板軟骨とそれ以外の組織においてCNPの調節機構が異なっていることを発見し、CNP発現調節機構解明とその低身長症への応用に向けた基礎を構築することができた。