2021 Fiscal Year Final Research Report
Development of autonomous insulin device for diabetic treatment
| Project/Area Number |
20K17530
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 糖尿病 / インスリン治療 / 血糖変動 / 糖尿病合併症 / 人工膵臓 / エレクトロニクスフリー |
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| Outline of Final Research Achievements |
Insulin therapy forms the basis of diabetes treatment, but it impairs quality of life and carries the risk of hypoglycemia. Recently, a number of studies have shown that blood glucose fluctuations pose the risk of vascular complications in addition to high blood glucose levels. Thus, the development of “artificial pancreas” that releases insulin responsively to blood glucose and does not cause fluctuations in blood glucose is imperative. Therefore, we have developed the electronics-free, easy-to-operate artificial pancreas-like device using the polymer gel containing phenylboronic acid whose physical properties change dramatically in response to glucose concentration. In this study, we evaluated the efficacy and safety of the device and its effect on blood glucose fluctuation and examined the possibility of clinical application.
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| Free Research Field |
生活習慣病
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| Academic Significance and Societal Importance of the Research Achievements |
近年の糖尿病治療では、単に血糖値を低下させるだけではなく、糖尿病合併症の予防に重点が置かれている。従来のインスリン治療は、糖尿病治療の根幹を成す一方で、患者や介護者のQOLを著しく損なう上、意識障害等の重篤な症状に繋がる低血糖の危険性を有する。本研究の成果により、エレクトロニクスフリーで高い機能性と安全性を有し、安価でコンパクトなインスリンデバイスの開発が実現し、糖尿病に対するインスリン治療のアンメット・メディカル・ニーズに応えることができる。特に、自律的なインスリン放出機能による低血糖や血糖値変動の抑制、高インスリン血症の軽減は、糖尿病合併症の予防に繋がると期待される。
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