2023 Fiscal Year Final Research Report
Basic research for artificial lungs using 3D stacking technology
Project/Area Number |
20K17577
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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Research Institution | Tokyo Women's Medical University (2022-2023) The University of Tokyo (2020-2021) |
Principal Investigator |
Hara Shintaro 東京女子医科大学, 医学部, 助教 (00791112)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | ECMO / 人工臓器 / 人工肺 / 光硬化 / 3Dプリンター / マイクロ流路 |
Outline of Final Research Achievements |
Among the components of ECMO, artificial lungs have the disadvantage of low durability and performance compared to blood pumps (artificial hearts) and must be replaced frequently. In this study, we proposed a three-dimensional laminated artificial lung as an artificial lung that can be used for a long period of time, surpassing the conventional hollow fiber membrane type artificial lung, and developed the basic principles of its manufacturing method and peripheral systems. As a result, a prototype model of the artificial lung, which is the main objective of this project, has been completed. We plan to make a presentation at a related academic conference in the future.
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Free Research Field |
生体工学
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Academic Significance and Societal Importance of the Research Achievements |
長期耐久を可能とした人工肺についてはECMOとしての成果にとどまらず、血液ポンプにおける人工心臓同様、体内埋め込み型人工肺に繋がる研究へのロードマップとなる。本邦においては臓器移植が下火であるため、異種移植などの研究も盛んに進んでいるが、医療機器の本質は汎用性のある使用と生体組織と比べて免疫反応を考えないという利点がある。 また現状の完成度でも、動物モデルとしては研究者が研究・製作しやすいことから汎用性も高いことやマイクロ流路という特性上他分野への展開も視野に考えることができ、学術的意義や社会的意義も高いと考えている。
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