2023 Fiscal Year Final Research Report
New graft preservation for the improvement of donation after cardiac death liver graft function.
| Project/Area Number |
20K17580
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 臓器保存 / 心停止肝移植 |
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| Outline of Final Research Achievements |
The outcome of donation after cardiac death (DCD) liver transplantation is worse compared with that of donation after brain death liver transplantation due to the long hypoxic period of donor warm ischemic time. We investigated the impact of improved graft oxygenation on liver ischemia-reperfusion injury (IRI) and survival after DCD liver transplantation. Biochemical and histopathologic analysis showed that liver graft preservation with oxygenation attenuated liver IRI and improved postoperative survival.
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| Free Research Field |
肝移植
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| Academic Significance and Societal Importance of the Research Achievements |
心停止後ドナーからの肝移植（心停止肝移植）はドナーの不足を補う新しい肝移植医療として注目されているが、肝臓（グラフト）の虚血時間が長くなることから、移植肝が長時間の低酸素状態にさらされる。
臓器保存液の酸素化を行う新規臓器保存法を取り入れることで、心停止肝移植の問題点である肝グラフトの虚血再灌流障害を軽減することができ、将来的に救命できる患者数を増加させることができる。
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