2022 Fiscal Year Annual Research Report
Modulation of circadian clock and its therapeutic implications in invasive breast carcinoma
| Project/Area Number |
20K17585
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | breast carcinoma |
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| Outline of Annual Research Achievements |
Based on our previous findings, we examined the level of mRNA expression of clock genes and histone modification markers in mouse and human breast carcinoma cells following treatment with D-glucose and D-allose. According to our observations, which are similar with earlier reports, treatment with D-glucose tended to increase glut1 mRNA expression, while D-allose treatment significantly reduced it. Interestingly, we found that the clock gene Cry2 expression was significantly upregulated in D-allose-treated-human and mouse breast cancer cells. Importantly, we observed that D-allose treatment reduced both the HDAC1 and HDAC2 mRNA expression. These data clearly indicate that there is a strong correlation with the histone modification with that of clock gene especially Cry2 in breast carcinoma.
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