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2022 Fiscal Year Final Research Report

Modulation of circadian clock and its therapeutic implications in invasive breast carcinoma

Research Project

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Project/Area Number 20K17585
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionKagawa University

Principal Investigator

Rahman Md Asadur  香川大学, 医学部, 助教 (30807285)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsbreast carcinoma / metastasis / circadian clock
Outline of Final Research Achievements

Our data indicated that Per1 and Per2 mRNA expression decreased in breast carcinoma cells compared to normal mammary tissue in mice. Since glucose metabolism has a significant impact on clock genes, we conducted pharmacological studies with rare sugar, D-allose. Cell proliferation was reduced after treatment with D-allose in mouse and human breast carcinoma cells. The gene expression data revealed that Per1, Per2 and Cry2 expression were increased after treatment with D-allose compared to the vehicle or D-glucose treatment. Based on our previous data, we analyzed the correlation of glut1 with those genes belong to the gene ontology of circadian rhythm. Interestingly, our data indicated that treatment with D-allose reduced the HDAC1 and HDAC2 gene expression compared to the control or equimolar D-glucose. Therefore, these data are in line with our hypothesis that modulation of circadian clock might be a potential therapeutic approach for invasive breast carcinoma.

Free Research Field

Cancer metabolism

Academic Significance and Societal Importance of the Research Achievements

Alteration of clock genes is highly associated with cancer cell proliferation and metastasis. Therefore, our findings indicated that modulating the circadian clock could be a remedial approach for attenuating metastasis as well as improved outcomes in patients with invasive breast carcinoma.

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Published: 2024-01-30  

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