Comprehensive Elucidation of the Mechanism of Cullin4A-mediated Esophageal Cancer Progression and Development of Novel Therapeutic Strategies

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17627
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Nara Medical University
• Principal Investigator: Nakade Hiroshi 奈良県立医科大学, 医学部附属病院, 研究員 (90745796)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: ユビキチン・プロテアソーム / 食道癌

Outline of Final Research Achievements

We confirmed that CUL4A overexpression affects tumors' proliferative, invasive, and migratory capacities. Next, we examined the effect of combining CUL4A overexpression with chemotherapy or radiotherapy to inhibit tumor growth. At the time of planning, we thought that the addition of chemotherapeutic agents or radiotherapy to a cell line with CUL4A activity inhibition would have a significantly favorable therapeutic effect due to their synergistic effects, but such a result was not achieved. However, this was not the case. The reason for this is thought to be that each treatment has its mechanism of action. We planned to create a liver metastasis model, but it did not grow well after transplantation. We will continue to investigate the cause and continue the experiment. We plan to summarize the above results and discuss them in a future issue.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

本研究ではヒト食道癌においてCUL4Aの発現と癌の進展機序を解明し，臨床応用可能な新たな集学的治療戦略の開発を目的である．CUL4Aは腫瘍増殖や浸潤，転移の重要な役割を担い，治療抵抗性の一因であるがゆえ，治療標的になりうるのではないかという点が本研究の成果の学術的意義や社会的意義と考える。