2022 Fiscal Year Final Research Report
Underlying mechanism of liver repair mediated by iNKT cells
| Project/Area Number |
20K17630
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 肝 / 虚血再灌流障害 / NKT細胞 / マクロファージ |
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| Outline of Final Research Achievements |
The role of NKT cells in liver tissue repair after hepatic ischemia-reperfusion injury was investigated. α-galactosylcerimide-treated activated NKT cells interacted with macrophages and produced IL-4 and IFN-γ, which accelerated the differentiation of macrophages accumulating in the liver and promoted liver repair. This interaction was demonstrated to be crucial for cytokine synthesis in the NKT cell-macrophage co-culture system. Activated NKT cells have the potential to enhance liver tissue repair after acute liver injury.
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| Free Research Field |
肝胆膵外科
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| Academic Significance and Societal Importance of the Research Achievements |
肝虚血再灌流後の肝組織修復が障害されると肝不全に至り患者予後は不良となる。これまでマクロファージの形質転換が肝修復に必須であるがその機序は不明であった。本研究において、NKT細胞とマクロファージの相互作用がマクロファージ形質転換に寄与して肝修復を促進することが明らかになった。NKT細胞を標的とした新しい肝再生治療開発に結びつく可能性が期待される。
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