Study of gastric cancer tissue heterogeneity approached from gastric signet-ring cell carcinoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17642
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: University of Yamanashi
• Principal Investigator: Saito Ryo 山梨大学, 大学院総合研究部, 医学研究員 (40866604)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 胃印環細胞癌 / マイクロRNA

Outline of Final Research Achievements

In this study, we investigated the microRNA expression that confers characteristic properties to early-stage signet-ring cell carcinoma and its mechanism of action.
We reported that high expression of miR-99a-5p were observed in patients with gastric signet-ring cell carcinoma, especially in patients with early-stage. We also found that miR-99a-5p expression was associated with cancer cell proliferation. Therefore, miR-99a-5p may be useful as a biomarker to diagnose early-stage signet-ring cell carcinoma, lymph node metastasis, or associated poor prognosis in patients.

Free Research Field

胃癌

Academic Significance and Societal Importance of the Research Achievements

早期印環細胞癌に得意的に高発現するマイクロRNAを同定した。遺伝子操作でこれを高発現させると癌の悪性度が低下することが明らかとなった。今後、癌の悪性獲得メカニズムの解明や、治療への応用の可能性が考えられる。