2022 Fiscal Year Final Research Report
Resarch of lipidome markers for monitoring multidisciplinary treatment of pancreatic cancer
Project/Area Number |
20K17643
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Tokyo Medical University (2021-2022) Nagoya University (2020) |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | リピドミクス / 膵癌 / 病勢モニタリング |
Outline of Final Research Achievements |
We tried to detect novel lipid monitoring markers for multimodally treated pancreatic cancer cases using patients’ serum samples-originated lipidome data. Exosome extraction was performed from 4 pancreatic cancer cases and 4 healthy controls, and lipidome analysis was conducted by the LC-MS analyzer. We found some candidate lipid molecules and accessed their recurrence or prognosis predicting ability using multi-timepoint serum samples of additional cohort of pancreatic cancer cases.
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Free Research Field |
消化器外科
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Academic Significance and Societal Importance of the Research Achievements |
血中のリピドームに着目し、ヒトの癌との関連を検討した研究は少数ながら存在する(Passos- Castilho AM, 2015, BMC cancer; Duscharla D, 2016, PLos One; Kim HY, 2017, Sci Rep)。しかし癌治療関連バイオマーカーの報告研究は未だなく、集学的治療中の膵癌病勢モニタリングに脂質バイオマーカーを適用した本研究は、新知見のある研究と言える。
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