Identification of HLA alleles associated with colorectal cancer risk and their correlation with postoperative chemotherapy response

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17668
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Showa University (2021-2023); National Cancer Center Japan (2020)
• Principal Investigator: Takayanagi Daisuke 昭和大学, 大学共同利用機関等の部局等, 兼任講師 (40595633)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 大腸がん / HLAアリル

Outline of Final Research Achievements

This study aims to elucidate the association between colorectal cancer (CRC) risk and human leukocyte antigen (HLA) alleles in the Japanese population. Using data from 6,854 CRC cases and 107,103 non-cancer controls registered in public databases such as the Bioscience Database Center, we perfoermd a genome-wide association study (GWAS). The results did not show a significant association between HLA alleles and CRC risk. Currently, further investigations are being conducted to examine the risks specific to different anatomical sites of the colon.

Free Research Field

ゲノム生物学

Academic Significance and Societal Importance of the Research Achievements

本研究は特定されたHLAアリルと大腸がんの関連性を明らかにすることで、リスクの高い個人を特定し、早期の介入や適切な治療を提供し、発症率や死亡率の低減に貢献します。また、術後化学療法や予後との関連性を検討することで、個別化医療の進展にも寄与します。現在のところ、大腸がん発症リスクとHLAアリルとの関連は認められていませんが、さらなる詳細な検討を継続していく予定です。