WNT Signaling in Esophageal Cancer - Mechanism of TCF Activity without Beta-catenin

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17698
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Nagoya City University
• Principal Investigator: Fujihata Shiro 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (10825483)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 食道癌 / β-catenin

Outline of Final Research Achievements

We compared the expression of βcatenin with prognostic and pathological factors in 171 clinical specimens of esophageal cancer by immunostaining, and found a trend toward an association between βcatenin expression and prognosis, but no significant results. In cellular experiments, esophageal cancer cells expressed more βcatenin than normal esophageal cells.

Free Research Field

食道癌

Academic Significance and Societal Importance of the Research Achievements

今回の検討では有意差は認められなかったが、食道癌においてはβcateninの発現量が予後に関連する可能性があると考えられた。