Development of a new myocardial regeneration therapy using autologous iPS cells for chronic myocardial infarction

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17710
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Shinshu University
• Principal Investigator: Ichimura Hajime 信州大学, 学術研究院医学系(医学部附属病院), 助教 (40749115)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 心筋細胞 / 多能性幹細胞 / 自家移植 / 細胞移植 / 心筋再生

Outline of Final Research Achievements

iPS cells were established from eight crab-eating macaques, and the required amount of cardiomyocyte differentiation was induced and cryopreserved.
During the research period, three autologous transplantation experiments were carried out , and the results leading to the continuation of the project (Fundamental C) were obtained.
(A patent application for the research is under consideration and details will be provided later.)

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

これまで明らかになっていなかった、自己の多能性幹細胞由来心筋細胞を用いた細胞移植に関しての免疫反応について大きな発見を行うことができ、またその制御方法についても有用な手段をみつけることができた。
本研究課題の発展内容である継続課題が完遂されれば、自家細胞を用いた心筋再生治療にむけての大きな前進となることが期待される。