A novel visualization technique of micro-metastasis.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17756
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Jichi Medical University
• Principal Investigator: Shibano Tomoki 自治医科大学, 医学部, 非常勤講師 (10648900)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: micrometastasis / dormancy / lung cancer

Outline of Final Research Achievements

In early-stage lung cancer, a certain proportion of patients have micrometastases that cannot be diagnosed preoperatively, which leads to distant metastases postoperatively. The diagnosis and treatment of these micrometastases are crucial for improving lung cancer treatment outcomes; however, research has been hampered by the lack of an appropriate in vivo model. We have developed a visualization model for micrometastases both in vivo and in tissue samples by utilizing AkaBLI, which has a higher detection capability than conventional Luciferase, for in vivo imaging in living animals, and by employing tissue clearing technology for fluorescent 3D imaging.

Free Research Field

Lung cancer

Academic Significance and Societal Importance of the Research Achievements

我々の作成した微小転移のin vivoモデルを治療や診断の研究に活用することで、さらなるがん治療の進歩が期待できる。