Mechanisms of maintaining cancer stem cells in lung squamous cell carcinoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17767
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Sugai Takahiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 共同研究員 (40869955)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 肺がん

Outline of Final Research Achievements

We have previously shown that CD271-positive cells are cancer stem cells of squamous cell lung cancer, that CD271 regulates tumorigenic potential, therapeutic resistance, proliferative capacity, and migratory ability, and that targeting CD271-positive cells has a tumor suppressive effect. On the other hand, the molecular mechanism of why CD271-positive cancer stem cells are generated and maintained remains unclear. We hypothesized that this maintenance mechanism could be a novel therapeutic target. In this project, we revealed that molecular X is required for the growth and stemness of squamous cell lung cancer in addition to CD271.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

私たちは肺扁平上皮がんにおけるあらたな分子標的Xを見出した。今後は更に検討を続けて、臨床応用を目指す