Identification of anaphylaxis-causing agents and identification of pathogenesis mechanisms using in vitro tests

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17803
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Gunma University
• Principal Investigator: Horiuchi Tatsuo 群馬大学, 大学院医学系研究科, 助教 (10814212)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: アナフィラキシー

Outline of Final Research Achievements

The basophil activation tests (BATs) and mast cell activation tests (MATs) were performed approximately as planned during this study, and the study could be carried out. However, some areas require further research. We plan to continue to elucidate the pathogenesis of anaphylaxis by conducting MAT and BAT in the future. The results may lead to developing new treatments and prophylactic agents for anaphylaxis.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

周術期アナフィラキシーの原因検索にこれまでほとんど行われてこなかったBATやMATに、本研究では取り組むことができた。本研究により、アナフィラキシーの発症メカニズムを検討することができた。今後のアナフィラキシーの予防や治療薬の開発につながると私達は考えている。