2022 Fiscal Year Final Research Report
Radical Therapy for neuropathic pain by fibroblast-derived induced Schwann cells
| Project/Area Number |
20K17826
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 神経障害性痛 / シュワン細胞 |
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| Outline of Final Research Achievements |
Sciatic nerve compression injury model rats were divided into three groups by transplantated cells: induced Schwann cells derived from human fibroblasts, rat Schwann cells, and no cell transplantation. . All rats with nerve compression injuries showed mechanical allodynia and thermal hyperalgesia after 1~2 weeks, but those treated with induced Schwann cells or rat Schwann cells showed a trend toward improvement 6 weeks after injury compared to the group without cell transplantation. Next, to analyze the kinetics of cells administered in the perineurium, we used lentivirus to infect human fibroblasts with AcGFP and examined the optimal conditions. The results showed that almost all cells were positive for GFP.
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| Free Research Field |
神経障害性痛
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は従来対症療法のみであった神経障害性痛治療に対して、新たな選択肢となる治療法の確率を目指している。神経障害性痛の動物モデルである、坐骨神経圧迫損傷モデルラットを用い、ヒト皮膚由来誘導シュワン細胞やラットシュワン細胞のいずれも治療効果を持つことを示した。
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