itochondria as target cell organelles of anesthetics and exploration of intracellular oxygen energy metabolism

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17850
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kansai Medical University
• Principal Investigator: OKAMOTO Akihisa 関西医科大学, 医学部, 研究員 (50509479)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: リドカイン / プロポフォール / ミトコンドリア / 酸素 / アポトーシス / ネクローシス

Outline of Final Research Achievements

It has been suggested that intravenous and local anesthetics may alter cellular metabolism, leading to cell death and subsequent systemic metabolic disturbances. The local anesthetic lidocaine and the intravenous anesthetic propofol have been shown to suppress mitochondria-dependent oxygen consumption and promote anaerobic metabolism at clinically relevant concentrations. Suppression of oxygen consumption was found to induce cell death.
Experimental evidence suggests that the mitochondrial electron transport system is a target of propofol and lidocaine in cellular injury.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

局所麻酔薬の神経障害、プロポフォール注入症候群の病態の分子機序の解明は麻酔科学が取り組むべき重要な課題である。いまだに病態の分子機構の詳細や発症予測因子・治療法の同定には至っていない。この問題に細胞機能に必須な役割を果たすミトコンドリアの酸素代謝の観点からのアプローチを試みた。この研究をさらに発展させることで安全な周術期管理を行う手掛かりが得られることが期待される。