Dielectric blood coagulometry for the early detection of sepsis-induced disseminated intravascular coagulation: A prospective observational study

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17854
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takayama Wataru 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50825502)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 敗血症 / DIC / 凝固障害

Outline of Final Research Achievements

Disseminated intravascular coagulation (DIC) is often life-threatening. However, its early detection is still challenging. Although thrombin is an ideal marker for real-time coagulation monitoring for DIC recognition, measuring thrombin levels is impractical in clinical settings. Recently, dielectric blood coagulometry (DBCM) was developed to evaluate whole blood coagulability and has been used to predict thrombosis and stroke risk. Our study evaluated the ability of DBCM to diagnose DIC in the early stage.

Free Research Field

集中治療

Academic Significance and Societal Importance of the Research Achievements

敗血症治療において、DICの早期認知は非常に臨床上非常に重要である。コアグロメーターが凝固障害を早期認知できた可能性を考慮すると、今後さまざまな分野への応用が可能となる。
各診療のガイドラインへ影響を与える可能性がある。