Establishment of objective and longitudinal sleep evaluation methods, including sleep-disordered breathing, in patients with acute respiratory failure.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17860
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Kyoto University
• Principal Investigator: Minami Takuma 京都大学, 医学研究科, 助教 (70866491)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 睡眠指標 / 睡眠時間 / 睡眠呼吸障害 / せん妄 / 呼吸不全

Outline of Final Research Achievements

In patients who were urgently hospitalized for acute respiratory failure and had delirium, sleep efficiency evaluated by a portable accelerometer was higher than in patients without delirium. This was thought to be due to the effects of sleeping pills or sedatives administered for delirium. A randomized controlled trial comparing dexmedetomidine and haloperidol for sedation in patients with hyperactive delirium at night who were urgently hospitalized is being conducted. It was revealed that sleep apnea and long sleep duration are predictors of atrial fibrillation recurrence in patients who underwent radiofrequency catheter ablation for persistent atrial fibrillation.

Free Research Field

呼吸器内科、救急医学

Academic Significance and Societal Importance of the Research Achievements

携帯型加速度計を用いて評価した急性呼吸不全患者の睡眠指標はせん妄との直接との関連ではなく、せん妄に対する投薬の影響を受ける可能性がある。これは、せん妄に対する薬剤による鎮静が重要な課題であることを示唆すると同時に、携帯型加速度計を用いて評価した睡眠指標は鎮静の程度を評価する指標となり得ることを示した。また、睡眠時無呼吸に加えて、携帯型加速度計による長時間睡眠は心房細動患者において、今後の研究課題となり得る重要な予測因子であることを示した。