2022 Fiscal Year Final Research Report
Role of the gut microbiota in early brain injury after subarachnoid hemorrhage
| Project/Area Number |
20K17863
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Osaka University |
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Principal Investigator |
Kawabata Shuhei 大阪大学, 大学院医学系研究科, 招へい教員 (20764062)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | くも膜下出血 / 早期脳損傷 / 腸内細菌 |
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| Outline of Final Research Achievements |
Early brain injury (EBI), which occurs promptly following subarachnoid hemorrhage (SAH), is crucial for the prognosis of SAH. Here, we evaluated whether prior gut microbiome (GM) alteration could prevent EBI following SAH. EBI was significantly averted by the GM alteration using antibiotics. The altered GM significantly prevented the inflammatory cells infiltration.These protective effects against EBI disappeared when the GM was recolonized with normal flora into the altered GM. Our findings demonstrated that the GM affects EBI following SAH by inflammatory cells regulation.
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| Free Research Field |
脳神経外科学
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| Academic Significance and Societal Importance of the Research Achievements |
EBIはSAHの予後に大きな影響を与えているものの、有効な治療法が未だ確立していない。本研究では、腸内細菌叢が炎症細胞を制御することでSAH後のEBIに影響を与えることを明らかにした。今後、EBIを予防するために腸内細菌叢を調整することが新たな治療戦略となる可能性が示唆され、SAHの予後を改善させる上で意義のある研究と考える。
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