2021 Fiscal Year Final Research Report
In vitro evaluation of alternative adsorbents to activated charcoal for treatment of acute poisoning
| Project/Area Number |
20K17906
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 55060:Emergency medicine-related
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2022-03-31
|
| Keywords | 活性炭 / 薬用炭 / 急性中毒 / 消化管除染 / 代替吸着材 / 超活性炭 / イオン交換樹脂 |
|---|
| Outline of Final Research Achievements |
Super activated charcoal, sodium polystyrene sulfonate which is a cation exchange resin, and cholestyramine which is an anion exchange resin, were evaluated as alternative adsorbents for substances (methanol, ethylene glycol, lead nitrate, thallium sulfate, lithium carbonate, potassium chloride, sodium bromate, and boric acid) for which activated charcoal was not effective.
The super activated charcoal and anion exchange resin showed only slight adsorption of all substances and boric acid, respectively, same as activated charcoal, and were not found to be useful as alternative adsorbents. On the other hand, the cation exchange resin adsorbed more lead, thallium, lithium, and potassium than activated charcoal, suggesting its usefulness as an alternative adsorbent.
|
| Free Research Field |
臨床中毒学、救急医学
|
| Academic Significance and Societal Importance of the Research Achievements |
超活性炭および陰イオン交換樹脂は吸着しなかったが、陽イオン交換樹脂は重金属や無機イオンに対して薬用炭より優れた吸着能を示し、代替吸着剤としての有用性が示唆された。重金属や無機イオンを誤って大量に摂取し中毒になる危険性がある場合、陽イオン交換樹脂による吸着療法が効果的である可能性が示された。
|
