Development of Nutrient Artery Chemoembolization Therapy for Malignant and Reluctant Meningiomas

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17915
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Yokohama City University (2023); University of Tsukuba (2020)
• Principal Investigator: AKIMOTO Taisuke 横浜市立大学, 医学部, 助教 (90846718)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 脳梗塞 / ELVO / カニクイザル / ナノ粒子

Outline of Final Research Achievements

Although the efficacy of thromboprophylaxis for treating occlusion of the main cerebral artery in the acute phase of stroke has been established, the challenge of managing worsened outcomes due to reperfusion injury remains. We aim to develop a novel cerebroprotective therapy to mitigate cerebral ischemia-reperfusion injury using our antioxidant nanoparticles. In our study, we established a monkey model of transient ischemia and investigated the efficacy and mechanism of action of 'antioxidant nanoparticles,' a polymeric micellar compound with antioxidant properties, over a 7-day administration period. Our evaluation demonstrated their superior efficacy and free radical scavenging activity.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

齧歯類ではなく、神経症状を確認できるカニクイサルの虚血再還流のモデルの作成ができたことは、血栓回収療法が広く広まっている現状で、新たな研究のモデルとしても使用可能であり、この分野の発展に寄与できるところがある。また、霊長類の虚血再還流で抗酸化ナノ粒子がの効果を示したことは、今後人に応用する上で重要な結果であり、脳梗塞治療の新たな一手になる可能性を示唆している。神経学的に、及び脳梗塞体積を減らす可能性があり、血栓回収療法の方法にも影響を与えうる可能性がある。