Development of new biomarkers for the detection of plaque rupture in patients with cervical internal carotid artery stenosis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17920
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Niigata University
• Principal Investigator: Ando Kazuhiro 新潟大学, 脳研究所, 非常勤講師 (20849004)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Podoplanine / CLEC-2 / 静脈血栓塞栓症 / 悪性神経膠腫

Outline of Final Research Achievements

In this study, we found that the sCLEC-2 level and C2PAC index tended to be higher in patients with IDH-wildtype high grade gliomas, which were suggested that the platelet activation was enhanced. In addition, we found that platelet activation is strongly involved in the development of VTE in patients with IDH-wildtype high grade gliomas as well as the coagulation system, which may be useful for elucidation the pathology of VTE and providing a new biomarker for VTE associated with IDH-wildtype high grade gliomas.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は術後に可溶型 CLEC-2 値を評価することで静脈血栓塞栓症合併をより 早期に予知・発見するが可能となり，臨床におけるより安全な術後管理に寄与できることが期待されます。