FGF-2 absorbed artificial dura mater for protective treatment of cerebral contusion

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17950
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: University of Tsukuba
• Principal Investigator: Ito Yoshiro 筑波大学, 医学医療系, 講師 (90733014)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳挫傷 / FGF-2 / PGA / FGF-2徐放システム

Outline of Final Research Achievements

In the preparation of FGF-2 adsorbed PGA, 0.5 W/cm2 plasma treatment was the most stable condition to adsorb FGF-2 on PGA. The amount of FGF-2 released could be adjusted by the concentration of FGF-2 solution and number of PGA sheets.
The effect of FGF-2 adsorbed PGA on a brain contusion model was examined. When FGF-2 adsorbed PGA was directly implanted at the site of brain contusion immediately after the creation of brain contusion, histological evaluation on day 14 showed an increase in neural progenitor cells and VEGF-positive cells around the brain contusion.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

脳挫傷の一次脳損傷に対する治療法は確立されておらず、神経後遺症をきたす主な原因となっている。本研究では急性期にFGF-2吸着PGAを用いることで神経前駆細胞の増加を認めたことから、脳挫傷の一次脳損傷に対する新規治療法となりうる可能性がある。また脳挫傷以外の二次性脳障害に対しても神経機能回復としての新規治療として期待できる。