Biomarker search for bone and soft tissue sarcoma using metabolome analysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18018
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Tohoku University
• Principal Investigator: Yoshida Shinichirou 東北大学, 大学病院, 助教 (50866548)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 骨軟部肉腫

Outline of Final Research Achievements

The purpose of this study was to search for biomarkers for bone and soft tissue sarcoma using metabolome analysis. The plan was to identify changes in the metabolic pathway through metabolome analysis of bone and soft tissue sarcoma samples removed during surgery, and to identify prognostic markers by evaluating the relationship with patient information and postoperative course. . Therefore, we have continued to collect patient information and patient samples for bone and soft tissue sarcoma since the start of the study. In order to perform metabolome analysis efficiently, it is necessary to collect a certain number of samples of the same tissue type, but since bone and soft tissue sarcoma is a rare disease, it takes time to collect multiple samples of the same tissue type. However, sufficient results were not obtained to detect changes that could serve as biomarkers.

Free Research Field

骨軟部肉腫

Academic Significance and Societal Importance of the Research Achievements

本研究では、骨軟部肉腫のメタボローム解析によるバイオマーカー探索を行ったが、数の少ない同一組織型のサンプルを用いるのみでは、有用なバイオマーカーとして提案しうる十分な結果を得ることができなかった。しかし、本研究を行うにあたり確立したデータベースを用いた臨床研究では、高齢者の軟部肉腫の手術で切除マージンが十分確保できなかった症例に対して放射線照射を追加することの意義や、骨軟部肉腫の手術待機期間と治療成績のには有意な関連がないことを確認した。これらの結果は、侵襲の大きな手術が許容されない高齢者における治療方針の選定や、手術時期の選定など、学術的・社会的意義のあるものであった。