2022 Fiscal Year Final Research Report
Nobel strategy and elucidation in fracture healing using Modulating Circadian rhythm
| Project/Area Number |
20K18030
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 骨折 / 概日リズム / 糖尿病 / メラトニン |
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| Outline of Final Research Achievements |
The biological clock (circadian rhythm) is controlled by clock genes. Changes in blood pressure, hormone secretion, and behavior reflect circadian rhythms. Clock genes have also been shown to be involved in the process of bone fracture healing. In this study, fractures were created in diabetic mice as a model of delayed bone healing. We attempted to artificially regulate circadian rhythms by administering melatonin, and compared the results with those of the normal group to see if it would promote bone healing.
The results showed that the expression of clock genes at the fracture site was altered in the normal, diabetic, and melatonin-treated groups. However, μCT and histological evaluation showed that delayed bone healing was not improved by only melatonin administration, suggesting that treatment of diabetes mellitus is important for diabetes-related delayed bone healing.
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| Free Research Field |
整形外科
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| Academic Significance and Societal Importance of the Research Achievements |
糖尿病は、罹病者数が非常に多い疾患であり、それに関連した有害事象も多い。今回の研究成果は、改めて糖尿病の治療の重要性を示すものであり、骨代謝に対しても糖尿病は多大な影響力を持つ。メラトニン投与により時計遺伝子の発現変化が示されたことは、薬剤投与が時計遺伝子を変動できる可能性を示しており、他の概日リズムによる生体反応への介入に応用できるかもしれない。
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