2022 Fiscal Year Final Research Report
Development of organoid panel from human sarcoma for establishment of novel treatment
Project/Area Number |
20K18048
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56020:Orthopedics-related
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Research Institution | Osaka International Cancer Institute |
Principal Investigator |
Wakamatsu Toru 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 整形外科 副部長 (90833476)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 肉腫 / オルガノイド |
Outline of Final Research Achievements |
We established more than transplantable 20 organoids from human sarcoma samples with organoid culture using collagen. We reported the study about 2 established epithelioid sarcoma organoids. In addition, we are planning to report about the established organoids of malignant giant cell tumor and liposarcoma. We also became able to perform the experiments about organoid growth, drug treatment and RNAi. We performed genetic analysis with established organoids to investigate the mechanism of malignant progression of sarcomas and treated with some drugs against those organoids. We demonstrated that continuing research of sarcoma organoid panel enable to establish novel treatment for sarcoma.
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Free Research Field |
骨軟部腫瘍
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Academic Significance and Societal Importance of the Research Achievements |
本研究は有効な治療法の少ない希少がんである肉腫を対象とした研究であること、また腫瘍本来の特徴を保持できる肉腫オルガノイドが樹立できたという報告は殆どなく社会的・学術的にも意義の大きいものであると考える。また樹立できたオルガノイドは継続的に使用可能であり研究材料の乏しい肉腫の分野においては非常に価値が高く、培養技術の更なる改良も視野に入れることで研究や治療の継続的な発展の礎になるものと考える。実際の医療情報と関連付けて更なる研究を行い、アンメットニーズに応えられるように進めていきたい。
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