2021 Fiscal Year Final Research Report
Comparison of penile human papillomavirus prevalence in Japanese men between self-sampling and doctor-sampling subjects
Project/Area Number |
20K18110
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | ヒトパピローマウイルス / 男性 / 陰茎 / 自己採取 / 性感染症 / スクリーニング |
Outline of Final Research Achievements |
Eighty-one male patients who attended urological clinic were enrolled in this study. From each participant, self-sampling and doctor-sampling subjects were collected by rubbing penile glans by cotton swab. After DNA was extracted from each subject, HPV-DNA test and genotyping were performed. HPV-DNA was detected in 31% of doctor-sampling and in 28% in self-sampling subjects, and 26% of patients had HPV detections in both samples. Compared to doctor-sampling subjects, sensitivity and specificity of HPV detection in self sampling were 91% and 93%, respectively. Complete or partial matching of HPV genotypes detected in both samples was 70%, suggesting that HPV type distribution in both samples was in good agreement. Use of self-sampling rubbed subjects may be useful for screening of penile HPV infection in men.
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Free Research Field |
尿路性器感染症
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Academic Significance and Societal Importance of the Research Achievements |
現在、様々なSTIsに対する自己採取法による検査が施行可能となっており、必ずしも医療機関を受診しなくても検査が可能になっている。HPVについても、女性を対象とした自己採取法によるHPV-DNA検査の有用性が確立されているが、男性については自己採取によるHPV検査は行われていない。本研究によって男性においても陰茎擦過による自己採取検体を用いたHPV検査は有用であると推察された。
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