Identification of substances causing skin pigmentation in end stage renal failure and development of removal column

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18141
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Okayama University
• Principal Investigator: Maruyama Yuki 岡山大学, 大学病院, 医員 (00803850)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 腎移植 / 末期腎不全 / 皮膚色素沈着

Outline of Final Research Achievements

On end-stage renal failure, skin complications (hyperpigmentation, dryness, itching) are an important condition affecting the patient's QoL. These skin pigmentation improves after living donor renal transplantation. Thus, a causative agent other than melanin, a common pigmentation agent, is assumed, however there is no report which identified. In this study, we aimed for comprehensive identification by proteome analysis.
One month after surgery, skin brightness was improved on the face, upper arms, and lower legs compared to the preoperative level. A non-significant improvement was also observed in the abdomen. Proteome analysis showed that the expression of keratin family members such as type I, type II, Elongin-B, AMBP, and PEBP-4 decreased after kidney transplantation, while FAM98C expression increased.

Free Research Field

腎移植、虚血再灌流障害

Academic Significance and Societal Importance of the Research Achievements

超高齢社会となった日本では、慢性腎臓病から、腎不全に至る患者が年々増加している。本邦では透析患者約33万人に対して腎移植数は少なく、透析患者の生産力の維持や、高齢者の自立が求められており、透析患者のQoL改善は社会的にますます重要となる。
本研究ではQoL低下をもたらす皮膚色素沈着物質を腎移植前後の皮膚検体を用いたプロテオーム解析を行い、網羅的に解析した。原因物質として複数のタンパクが同定できており、今後さらなる研究を行い、除去法を策定することで、腎不全患者のみならず、健常人の皮膚色・保湿に発展していける可能性がある。