2022 Fiscal Year Final Research Report
Association between pathological injury of acute T cell-mediated rejection and autophagy in kidney tranpslantation
| Project/Area Number |
20K18145
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 腎移植 / 拒絶 / 喫煙 |
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| Outline of Final Research Achievements |
The main results are described in below.
First, histological injury and therapeutic responsiveness; this study revealed that therapeutic responsiveness in chronic active T-cell-related rejection were closely associated with acute lesion in kidney transplant biopsy.
Second, relationship between smoking history and tissue injury in kidney transplant donors; Using 0-hour biopsies at the time of nephrectomy from kidney transplant donors, we examined the relationship between smoking history and tissue injury. Smoking history was not associated with renal function, but histologically showed a strong association with hyaline changes in arterioles.
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| Free Research Field |
腎臓内科
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| Academic Significance and Societal Importance of the Research Achievements |
①慢性活動性T細胞関連拒絶の組織学的傷害度と治療反応性：既報では腎予後が悪いことがすでに示されているが，しかし，実際の経過は様々である．今回の検討では，治療選択の一助になるものと思われる．
②腎移植ドナーの喫煙歴と組織傷害の関連性：喫煙歴は慢性腎臓病の危険因子であるが，その病理学的な早期病変については充分検討されていなかった．喫煙の早期病変が血管病変が主体であることが示唆された．この結果は，アメリカ腎臓学会で発表され，現在論文
投稿中である．
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