Regenerative medicine frontier research targeting mesenchymal cells for the treatment of congenital upper urinary tract abnormalities.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18150
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Jichi Medical University (2021-2022); Wakayama Medical University (2020)
• Principal Investigator: Hyuga Taiju 自治医科大学, 医学部, 講師 (50741279)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 尿路 / 間葉

Outline of Final Research Achievements

In the field of pediatric urology, we performed various regenerative studies to treat abnormalities of the kidney and urinary tracts (kidney, ureter, bladder, urethra, etc.). Since an assay system for analyzing the condition of the urinary tract is necessary, we established the assay system for the urinary tract in mice for the first time in the world. Utilizing contrast agent and other techniques, we reported on the anatomy of the mouse urethra. Utilizing the assay system, we are now elucidating the pathology that causes inflammatory changes in the epithelium and mesenchyme after urinary extravasation and subsequent fibrosis of the mesenchyme to the ductal organs.

Free Research Field

泌尿器

Academic Significance and Societal Importance of the Research Achievements

小児泌尿器科領域において、尿路の異常の基礎的なメカニズムの解明についてはエビデンスが不足している状況であり、未だわかっていないことが多い。それを解明するために動物実験を行い、情報を蓄積していく必要がある。本研究では、今まで不明であったマウスの尿路の解剖、評価系を開発した(Scientific Reports 2020 Hyuga et al、及び投稿中)。加えて、手術後合併症の発症機序としての病態予後の解明を行った。管腔臓器特有の病態としての　尿漏出後の病態について解明を行いつつある。